This product was formerly named Nanotrap® Magnetic Virus Particles.
Nanotrap® Microbiome Particles
Nanotrap Microbiome Particles rapidly concentrate microbes from many sample types, eliminating the need for filtration precipitation or centrifugation.
Large-scale wastewater surveillance can be used to help communities monitor infection dynamics for SARS-CoV-2 and other microbes of concern. Robust, high-throughput methods based on Nanotrap Microbiome Particles are enabling widespread implementation.

For Research Use Only. Not for use in diagnostic procedures.
- Nanotrap particles utilize affinity capture and enrichment to attract and bind low abundance viruses.
- Methods developed for clinical swab samples, saliva, urine, wastewater, food wash and blackwater.
- Compatible with PCR, sequencing or immunoassay analysis methods.
- Successfully utilized in high-complexity and point-of-care RT-PCR assays with FDA Emergency Use Authorization for COVID-19.
- Nanotrap particles do not utilize antibodies or other biomolecules as affinity molecules, which means extended room temperature stability.
Nanotrap Products
Nanotrap Microbiome A Particles
The Nanotrap Microbiome A Particles have a broad affinity for a wide range of microbes and can capture and concentrate influenza A, influenza B, respiratory syncytial virus, coronavirus 229E, coronavirus OC43, SARS-CoV-2, Zika virus, Chikungunya virus, dengue virus, pepper mild mottle virus, hepatitis A virus and mpox virus.
Nanotrap Microbiome B Particles
The Nanotrap Microbiome B Particles have been demonstrated to capture and concentrate a wide range of microbes, including Escherichia coli, Salmonella enterica, Campylobacter jejuni, Listeria monocytogenes, Clostridioides difficile and crASSphage.
Nanotrap Enhancement Reagents
Nanotrap Microbiome Particles rapidly capture and concentrate microbes from raw sewage requiring no filtration or centrifugation. Using Nanotrap Enhancement Reagents with the Nanotrap particles improves the binding of microbes in these samples, further improving downstream detection of nucleic acids.
A growing list of microbes have been captured and concentrated with the Nanotrap Microbiome Particles. If you don’t see the microbe of interest on this list, please contact us to discuss your application.
Features
- Designed to capture and concentrate a variety of microbes.
- Provide a simple and rapid approach for concentration of microbes from various sample types.
- Utilize affinity capture and enrichment technology to bind low abundance targets.
- Wastewater processing protocols are available for manual or automated workflows.
Benefits
- Increase sensitivity of existing SARS-CoV-2 assay by capturing and concentrating whole virus.
- Compatible with RT-qPCR, RT-ddPCR, RT-dPCR, and sequencing-based analysis methods.
- Manual and automated protocols available for use with a wide range of nucleic acid extraction kits.
- Enable rapid and simple automated or manual methods for preparing wastewater samples for nucleic acid extraction.
- Replace filtration and centrifugation methods, without sacrificing assay sensitivity.
- Improve microbe detection in wastewater samples by at least 1-2 Ct values using Nanotrap Enhancement Reagents with Nanotrap Microbiome Particles.
- Concentrate microbes from 24 wastewater samples in 40 minutes, faster than other automated methods such as PEG precipitation or ultracentrifugation.
Sample processing time comparison


Ordering Information
Description | Catalog Number |
---|---|
Nanotrap Microbiome A Particles 10 mL Vial | 250068 |
Nanotrap Microbiome A Particles 30 mL Vial | 250069 |
Nanotrap Microbiome B Particles 10 mL Vial | 250075 |
Nanotrap Microbiome B Particles 30 mL Vial | 250076 |
Nanotrap Enhancement Reagent 1 (ER1) 10 mL | 250070 |
Nanotrap Enhancement Reagent 2 (ER2) 10 mL | 250071 |
Nanotrap Enhancement Reagent 3 (ER3) 10 mL | 250077 |
Nanotrap Enhancement Reagent 1 (ER1) 30 mL | 250072 |
Nanotrap Enhancement Reagent 2 (ER2) 30 mL | 250073 |
Nanotrap Enhancement Reagent 3 (ER3) 30 mL | 250078 |
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Citations
Resources
Wastewater Manual Protocol
Wastewater Auto Protocol


How Nanotrap Technology for Wastewater Surveillance Improves SARS-CoV-2 Workflows


How Nanotrap Particle Technology is Improving the Public Health Response to SARS-CoV-2
Nanotrap Microbiome Particles compatibility across different nucleic acid extraction kits | |||||
Vendor | Extraction Kit | SKU | Particles | ||
Nanotrap Microbiome A | Nanotrap Microbiome B | ||||
Enhancement Reagent 1 | Enhancement Reagent 2 | Enhancement Reagent 3 | |||
MACHEREY-NAGEL | NucleoMag DNA/RNA Water Kit | 744220.1 | X | X | |
Applied Biosystems™ | MagMAX™ Viral/Pathogen Nucleic Acid Extraction Kit | A42352 | X | X | |
Applied Biosystems™ | MagMAX™ Viral/Pathogen II (MVP II) Nucleic Acid Extraction Kit | A48383 | X | X | |
Applied Biosystems™ | MagMAX™ Microbiome Ultra Nucleic Acid Kit | A42357 | X | X | |
QIAGEN | MagAttract® Viral RNA Kit (960) | 955538 | X | X | |
QIAGEN | QIAamp® Viral RNA Mini Kit (250) | 52906 | X | X | |
QIAGEN | AllPrep® PowerViral® DNA/RNA Kit (50) | 28000-50 | X | X | |
Zymo Research | ZymoBIOMICS™ MagBead DNA/RNA Kit | R2135 | X | ||
Promega | Maxwell® HT Environmental TNA Kit, Custom | AX9190 | X | ||
IDEXX | Water DNA/RNA Magnetic Bead Kit | 98-0014719-00 | X |
All trademarks are the property of their respective owners
Instructions (IFU)
Certificates
- Nanotrap Microbiome A Particles Lot NT04455 2023-11-12 CoA
- Nanotrap Microbiome A Particles Lot NT04473 2024-03-02 CoA
- Nanotrap Enhancement Reagent 1 Lot NT04854 2023-11-16 CoC
- Nanotrap Enhancement Reagent 1 Lot NT05120 2024-04-11 CoC
- Nanotrap Enhancement Reagent 2 Lot NT04856 2023-11-16 CoC
- Nanotrap Enhancement Reagent 2 Lot NT05327 2024-08-30 CoC
SDS
Product Information
- Nanotrap Microbiome Particles Brochure
- Can Sewer Networks Tell Us Where COVID-19 Transmission Occurs
- Quantifying the Relationship Between SARS-CoV-2 Wastewater Concentrations
- Early Detection through Rapid Wastewater Surveillance and Reporting
- Wastewater Sequencing Uncovers Early, Cryptic SARS-CoV-2 Variant Transmission
- Nanotrap® Microbiome A and B Particles can be Combined to Improve Microbe Capture from Wastewater
Application Notes
Protocols
- Manual Nanotrap® Wastewater Protocol using QIAGEN AllPrep® PowerViral® DNA-RNA Kit
- Manual Nanotrap® Wastewater Protocol using QIAGEN QIAamp® Viral RNA Mini Kit
- Automated Nanotrap® Wastewater Protocol using QIAGEN MagAttract® Viral RNA Kit
- Manual Nanotrap® Wastewater Protocol using NucleoMag Kit
- Automated Nanotrap® Wastewater Protocol using NucleoMag Kit
- Manual Nanotrap® Wastewater Protocol using IDEXX Water DNA-RNA Magnetic Bead Kit
- Automated Nanotrap® Wastewater Protocol using IDEXX Water DNA-RNA Magnetic Bead Kit
- Manual Nanotrap® Wastewater Protocol using MagMAX Kits
- Automated Nanotrap® Wastewater Protocol using MagMAX Kits
- Manual Nanotrap® Wastewater Protocol using Promega Maxwell® HT Environmental TNA Kit
- Automated Nanotrap® Wastewater Protocol using Promega Maxwell® HT Environmental TNA Kit
- Manual Nanotrap® Wastewater Protocol using ZymoBIOMICS® MagBead DNA-RNA Kit
- Automated Nanotrap® Wastewater Protocol using ZymoBIOMICS® MagBead DNA-RNA Kit
Looking for an older document? Click here for archived assays and certificates.
Molecular Products
Molecular Diagnostics (MDx) are the tests and techniques that have been developed in recent decades that analyze biological markers such as nucleic acids and proteins, to diagnose and monitor disease, detect disease risks and to monitor the effectiveness of treatments. MDx assays are used in prenatal testing, infectious disease testing, cancer and inherited diseases testing.

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