This product was formerly named Nanotrap® Magnetic Virus Particles.

Nanotrap® Microbiome Particles

Nanotrap Microbiome Particles rapidly concentrate microbes from many sample types, eliminating the need for filtration precipitation or centrifugation.

Large-scale wastewater surveillance can be used to help communities monitor infection dynamics for SARS-CoV-2 and other microbes of concern. Robust, high-throughput methods based on Nanotrap Microbiome Particles are enabling widespread implementation. 

Ceres Nanotrap Microbiome A & B bottles

For Research Use Only. Not for use in diagnostic procedures.

  • Nanotrap particles utilize affinity capture and enrichment to attract and bind low abundance viruses.
  • Methods developed for clinical swab samples, saliva, urine, wastewater, food wash and blackwater.
  • Compatible with PCR, sequencing or immunoassay analysis methods.
  • Successfully utilized in high-complexity and point-of-care RT-PCR assays with FDA Emergency Use Authorization for COVID-19.
  • Nanotrap particles do not utilize antibodies or other biomolecules as affinity molecules, which means extended room temperature stability.

TECHNICAL DOCUMENTS

 

Nanotrap Products​

Nanotrap Microbiome A Particles

The Nanotrap Microbiome A Particles have a broad affinity for a wide range of microbes and can capture and concentrate influenza A, influenza B, respiratory syncytial virus, coronavirus 229E, coronavirus OC43, SARS-CoV-2, Zika virus, Chikungunya virus, dengue virus, pepper mild mottle virus, hepatitis A virus and mpox virus.

Nanotrap Microbiome B Particles

The Nanotrap Microbiome B Particles have been demonstrated to capture and concentrate a wide range of microbes, including Escherichia coli, Salmonella enterica, Campylobacter jejuni, Listeria monocytogenes, Clostridioides difficile and crASSphage.

Nanotrap Enhancement Reagents​

Nanotrap Microbiome Particles rapidly capture and concentrate microbes from raw sewage requiring no filtration or centrifugation. Using Nanotrap Enhancement Reagents with the Nanotrap particles improves the binding of microbes in these samples, further improving downstream detection of nucleic acids.

Ordering Information

A growing list of microbes have been captured and concentrated with the Nanotrap Microbiome Particles. If you don’t see the microbe of interest on this list, please contact us to discuss your application.

Features

  • Designed to capture and concentrate a variety of microbes.
  • Provide a simple and rapid approach for concentration of microbes from various sample types.
  • Utilize affinity capture and enrichment technology to bind low abundance targets.
  • Wastewater processing protocols are available for manual or automated workflows.

Benefits

  • Increase sensitivity of existing SARS-CoV-2 assay by capturing and concentrating whole virus.
  • Compatible with RT-qPCR, RT-ddPCR, RT-dPCR, and sequencing-based analysis methods.
  • Manual and automated protocols available for use with a wide range of nucleic acid extraction kits.
  • Enable rapid and simple automated or manual methods for preparing wastewater samples for nucleic acid extraction.
  • Replace filtration and centrifugation methods, without sacrificing assay sensitivity.
  • Improve microbe detection in wastewater samples by at least 1-2 Ct values using Nanotrap Enhancement Reagents with Nanotrap Microbiome Particles.
  • Concentrate microbes from 24 wastewater samples in 40 minutes, faster than other automated methods such as PEG precipitation or ultracentrifugation.

Sample processing time comparison

PEG Precipitation Processing Time
Nanotrap Microbiome Particles Processing Time

Ordering Information

DescriptionCatalog Number
 
Nanotrap Microbiome A Particles 10 mL Vial250068
Nanotrap Microbiome A Particles 30 mL Vial250069
Nanotrap Microbiome B Particles 10 mL Vial250075
Nanotrap Microbiome B Particles 30 mL Vial250076
Nanotrap Enhancement Reagent 1 (ER1) 10 mL250070
Nanotrap Enhancement Reagent 2 (ER2) 10 mL250071
Nanotrap Enhancement Reagent 3 (ER3) 10 mL250077
Nanotrap Enhancement Reagent 1 (ER1) 30 mL250072
Nanotrap Enhancement Reagent 2 (ER2) 30 mL250073
Nanotrap Enhancement Reagent 3 (ER3) 30 mL250078

 

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Citations

Resources

 

Wastewater Manual Protocol

 

Wastewater Auto Protocol

Member of the University of Massachusetts, Amherst SARS-CoV-2wastewater surveillance team
UMass Amherst school logo

How Nanotrap Technology for Wastewater Surveillance Improves SARS-CoV-2 Workflows

Read the interview
University of Nevada, Reno school logo

How Nanotrap Particle Technology is Improving the Public Health Response to SARS-CoV-2

Read the interview

Nanotrap Microbiome Particles compatibility across different nucleic acid extraction kits

Vendor

Extraction Kit 

SKU

Particles

Nanotrap Microbiome A

Nanotrap Microbiome B

Enhancement Reagent 1

Enhancement Reagent 2

Enhancement Reagent 3

MACHEREY-NAGEL

NucleoMag DNA/RNA Water Kit

744220.1

X

X

Applied Biosystems™

MagMAX™ Viral/Pathogen Nucleic Acid Extraction Kit

A42352

X

X

Applied Biosystems™

MagMAX™ Viral/Pathogen II (MVP II) Nucleic Acid Extraction Kit

A48383

X

X

Applied Biosystems™

MagMAX™ Microbiome Ultra Nucleic Acid Kit

A42357

X

X

QIAGEN

MagAttract® Viral RNA Kit (960)

955538

X

X

QIAGEN

QIAamp® Viral RNA Mini Kit (250)

52906

X

X

QIAGEN

AllPrep® PowerViral® DNA/RNA Kit (50)

28000-50

X

X

Zymo Research

ZymoBIOMICS™ MagBead DNA/RNA Kit

R2135

X

Promega

Maxwell® HT Environmental TNA Kit, Custom

AX9190

X

IDEXX

Water DNA/RNA Magnetic Bead Kit

98-0014719-00

X

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Instructions (IFU)

Certificates

SDS

Product Information

Application Notes

Protocols

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