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Webinar: What Lies Beneath: Wastewater Testing for Pathogens
Wastewater-based epidemiology (WBE) is a powerful tool for monitoring the emergence of infectious pathogens. While WBE has been around since the 1800s…
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This product was formerly named Nanotrapยฎ Magnetic Virus Particles.
Nanotrapยฎ Microbiome Particles
Nanotrap Microbiome Particles rapidly concentrate microbes from many sample types, eliminating the need for filtration precipitation or centrifugation.
Large-scale wastewater surveillance can be used to help communities monitor infection dynamics for SARS-CoV-2 and other microbes of concern. Robust, high-throughput methods based on Nanotrap Microbiome Particles are enabling widespread implementation.
- Nanotrap particles utilize affinity capture and enrichment to attract and bind low abundance viruses.
- Methods developed for clinical swab samples, saliva, urine, wastewater, food wash and blackwater.
- Compatible with PCR, sequencing or immunoassay analysis methods.
- Successfully utilized in high-complexity and point-of-care RT-PCR assays with FDA Emergency Use Authorization for COVID-19.
- Nanotrap particles do not utilize antibodies or other biomolecules as affinity molecules, which means extended room temperature stability.
Nanotrap Productsโ
Nanotrap Microbiome A Particles
The Nanotrap Microbiome A Particles have a broad affinity for a wide range of microbes and can capture and concentrate influenza A, influenza B, respiratory syncytial virus, coronavirus 229E, coronavirus OC43, SARS-CoV-2, Zika virus, Chikungunya virus, dengue virus, pepper mild mottle virus, hepatitis A virus and mpox virus.
Nanotrap Microbiome B Particles
The Nanotrap Microbiome B Particles have been demonstrated to capture and concentrate a wide range of microbes, including Escherichia coli, Salmonella enterica, Campylobacter jejuni, Listeria monocytogenes, Clostridioides difficile and crASSphage.
Nanotrap Enhancement Reagentsโ
Nanotrap Microbiome Particles rapidly capture and concentrate microbes from raw sewage requiring no filtration or centrifugation. Using Nanotrap Enhancement Reagents with the Nanotrap particles improves the binding of microbes in these samples, further improving downstream detection of nucleic acids.
Nanotrap Buffer 2
Nanotrap Buffer 2 improves microbe recovery with Ceres Nanotrap Microbiome Particles when using a manual method. Nanotrap Buffer 2 homogenizes solids, dilutes viscous samples and facilitates movement of Nanotrap Microbiome Particles between tubes.
A growing list of microbes have been captured and concentrated with the Nanotrap Microbiome Particles. If you donโt see the microbe of interest on this list, please contact us to discuss your application.
Features
- Designed to capture and concentrate a variety of microbes.
- Provide a simple and rapid approach for concentration of microbes from various sample types.
- Utilize affinity capture and enrichment technology to bind low abundance targets.
- Wastewater processing protocols are available for manual or automated workflows.
Benefits
- Increase sensitivity of existing SARS-CoV-2 assay by capturing and concentrating whole virus.
- Compatible with RT-qPCR, RT-ddPCR, RT-dPCR, and sequencing-based analysis methods.
- Manual and automated protocols available for use with a wide range of nucleic acid extraction kits.
- Enable rapid and simple automated or manual methods for preparing wastewater samples for nucleic acid extraction.
- Replace filtration and centrifugation methods, without sacrificing assay sensitivity.
- Improve microbe detection in wastewater samples by at least 1-2 Ct values using Nanotrap Enhancement Reagents with Nanotrap Microbiome Particles.
- Concentrate microbes from 24 wastewater samples in 40 minutes, faster than other automated methods such as PEG precipitation or ultracentrifugation.
Sample processing time comparison
Ordering Information
| Description | Catalog Number |
|---|---|
| Nanotrap Microbiome A Particles 10 mL Vial | 250068 |
| Nanotrap Microbiome A Particles 30 mL Vial | 250069 |
| Nanotrap Microbiome B Particles 10 mL Vial | 250075 |
| Nanotrap Microbiome B Particles 30 mL Vial | 250076 |
| Nanotrap Enhancement Reagent 1 (ER1) 10 mL | 250070 |
| Nanotrap Enhancement Reagent 2 (ER2) 10 mL | 250071 |
| Nanotrap Enhancement Reagent 3 (ER3) 10 mL | 250077 |
| Nanotrap Buffer 2 100 mL | 250081 |
| Nanotrap Enhancement Reagent 1 (ER1) 30 mL | 250072 |
| Nanotrap Enhancement Reagent 2 (ER2) 30 mL | 250073 |
| Nanotrap Enhancement Reagent 3 (ER3) 30 mL | 250078 |
Order Nanotrap Microbiome Particles today
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Existing customers
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Citations
Resources
Wastewater Manual Protocol
Wastewater Auto Protocol
Technical Note
Combining Nanotrap Particle-based capture and concentration with qPCR analysis using the Streck ARM-D Kits creates a consistent and reliable protocol for wastewater AMR surveillance.
What Lies Beneath: Wastewater Testing for Pathogens
Dr. Michael Wiley discusses the wastewater surveillance program in Nebraska and describes how wastewater-based epidemiology can protect communities from future outbreaks.
How Nanotrap Technology for Wastewater Surveillance Improves SARS-CoV-2 Workflows
How Nanotrap Particle Technology is Improving the Public Health Response to SARS-CoV-2
Nanotrap Microbiome Particles compatibility across different nucleic acid extraction kits | |||||
Vendor | Extraction Kit | SKU | Particles | ||
Nanotrap Microbiome A | Nanotrap Microbiome B | ||||
Enhancement Reagent 1 | Enhancement Reagent 2 | Enhancement Reagent 3 | |||
MACHEREY-NAGEL | NucleoMag DNA/RNA Water Kit | 744220.1 | X | X | |
Applied Biosystems™ | MagMAX™ Viral/Pathogen Nucleic Acid Extraction Kit | A42352 | X | X | |
Applied Biosystems™ | MagMAX™ Viral/Pathogen II (MVP II) Nucleic Acid Extraction Kit | A48383 | X | X | |
Applied Biosystems™ | MagMAX™ Microbiome Ultra Nucleic Acid Kit | A42357 | X | X | |
QIAGEN | MagAttract® Viral RNA Kit (960) | 955538 | X | X | |
QIAGEN | QIAamp® Viral RNA Mini Kit (250) | 52906 | X | X | |
QIAGEN | AllPrep® PowerViral® DNA/RNA Kit (50) | 28000-50 | X | X | |
Zymo Research | ZymoBIOMICS™ MagBead DNA/RNA Kit | R2135 | X | ||
Promega | Maxwell® HT Environmental TNA Kit, Custom | AX9190 | X | ||
IDEXX | Water DNA/RNA Magnetic Bead Kit | 98-0014719-00 | X | ||
All trademarks are the property of their respective owners
Protocols
APP-075 R01 Automated Nanotrap Microbiome A and B Enviro Water Protocol using MagMAX Kit_10 mL
APP-090 R00 Nanotrap Microbiome Combined_ 10mL Manual Protocol with AllPrep PowerViral DNA RNA Mini Kit
APP-098 R00 Nanotrap Microbiome A 10mL Automated Protocol with MagMAX Kit and KingFisher Flex
Instructions (IFU)
Product Information
- Nanotrap Microbiome Particles Brochure
- Can Sewer Networks Tell Us Where COVID-19 Transmission Occurs
- Quantifying the Relationship Between SARS-CoV-2 Wastewater Concentrations
- Early Detection through Rapid Wastewater Surveillance and Reporting
- Wastewater Sequencing Uncovers Early, Cryptic SARS-CoV-2 Variant Transmission
- Nanotrapยฎ Microbiome A and B Particles can be Combined to Improve Microbe Capture from Wastewater
- Improved AMR Detection in Wastewater
Application Notes
Certificates
- Nanotrap Microbiome A Particles Lot NT04455 11-12-2023 CoA
- Nanotrap Microbiome A Particles Lot NT04465 02-11-2024 CoA
- Nanotrap Microbiome A Particles Lot NT04473 03-02-2024 CoA
- Nanotrap Microbiome A Particles Lot NT04342 03-18-2027 CoA
- Nanotrap Enhancement Reagent 1 Lot NT04854 11-16-2023 CoC
- Nanotrap Enhancement Reagent 1 Lot NT05120 04-11-2024 CoC
- Nanotrap Enhancement Reagent 2 Lot NT04856 11-16-2023 CoC
- Nanotrap Enhancement Reagent 2 Lot NT05327 08-30-2024 CoC
- Nanotrap Buffer 2 Batch No NT05760 03-30-2025 CoC
- Nanotrap Buffer 2 Batch No NT05761 03-30-2025 CoC
- Nanotrap Buffer 2 Batch No NT05762 03-30-2025 CoC
- Nanotrap Buffer 2 Batch No NT05763 03-30-2025 CoC
- Nanotrap Buffer 2 Batch No NT05769 03-31-2025 CoC
- Nanotrap Buffer 2 Batch No NT05770 03-31-2025 CoC
- Nanotrap Buffer 2 Batch No NT05771 03-31-2025 CoC
- Nanotrap Buffer 2 Batch No NT05782 04-06-2025 CoC
- Nanotrap Buffer 2 Batch No NT05783 04-06-2025 CoC
- Nanotrap Buffer 2 Batch No NT05784 04-06-2025 CoC
- Nanotrap Buffer 2 Batch No NT05836 04-25-2025 CoC
- Nanotrap Buffer 2 Batch No NT05837 04-25-2025 CoC
- Nanotrap Buffer 2 Batch No NT05841 04-26-2025 CoC
- Nanotrap Buffer 2 Batch No NT05842 04-26-2025 CoC
- Nanotrap Buffer 2 Batch No NT05863 05-10-2025 CoC
- Nanotrap Buffer 2 Batch No NT05864 05-10-2025 CoC
- Nanotrap Buffer 2 Batch No NT05865 05-10-2025 CoC
- Nanotrap Buffer 2 Batch No NT05866 05-10-2025 CoC
- Nanotrap Buffer 2 Batch No NT05867 05-10-2025 CoC
- Nanotrap Buffer 2 Batch No NT05868 05-10-2025 CoC
- Nanotrap Buffer 2 Batch No NT05869 05-10-2025 CoC
- Nanotrap Buffer 2 Batch No NT05870 05-10-2025 CoC
SDS
Looking for an older document? Click here for archived assays and certificates.
Molecular Products
Molecular Diagnostics (MDx) are the tests and techniques that have been developed in recent decades that analyze biological markers such as nucleic acids and proteins, to diagnose and monitor disease, detect disease risks and to monitor the effectiveness of treatments. MDx assays are used in prenatal testing, infectious disease testing, cancer and inherited diseases testing.
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