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Protein Plus BCT is a direct draw whole blood collection tube intended for the stabilization of draw-time concentrations of plasma proteins for up to 5 days* at ambient temperature. Protein Plus BCT contains a preservative reagent that minimizes ex vivo hemolysis and platelet activation in collected samples, limits interference of proteins released from blood cells and maintains draw-time concentrations of plasma proteins during whole blood storage.
*Depending on protein
For Research Use Only. Not for use in diagnostic procedures.
Protein Plus BCT should only be used for research or the development of new assays.
Stabilizes plasma protein markers of interest
Limits ex vivo platelet activation and hemolysis
Compatible with mass spectrometry and immunoassay-based proteomic analysis
Minimizes contamination of blood cell-secreted proteins into plasma, providing sample integrity during storage and handling of blood samples
Reduces the need for immediate sample processing and analysis
Allows for the batching of samples, optimizing laboratory workflow
| Description | Item Number |
|---|---|
| 6-tube pack (5.0 mL), RUO | 230627 |
| 100-tube pack (5.0 mL), RUO | 230628 |
| 1000-tube pack (5.0 mL), RUO | 230629 |
Protein Plus BCT is a direct draw whole blood collection tube intended for the stabilization of draw-time concentrations of plasma proteins for up to 5 days at ambient temperature. It is designed for research applications involving proteomic analysis, including mass spectrometry and immunoassay-based studies of plasma protein biomarkers.
Protein Plus BCT reduces contamination from blood cell-secreted proteins into plasma, maintaining draw-time concentrations of plasma proteins of interest during whole blood storage at ambient temperature.
Hemolysis (red blood cell breakdown) and platelet activation can release large amounts of intracellular proteins into plasma, contaminating the sample and interfering with accurate measurement of plasma protein biomarkers. Protein Plus BCT minimizes these effects, providing sample integrity during storage and handling and ensuring that protein measurements reflect true circulating levels rather than artifacts of sample processing.
Protein Plus BCT is compatible with both mass spectrometry and immunoassay-based proteomic analysis platforms. This broad compatibility allows researchers to use the tube for various protein quantification and characterization methods without workflow modifications.
Yes, Protein Plus BCT allows for the batching of samples, optimizing laboratory workflow. The 5-day stability at ambient temperature reduces the need for immediate sample processing and analysis, enabling laboratories to accumulate samples and process them in efficient batches rather than individually as they arrive.
Protein biomarker research faces significant pre-analytical challenges because traditional blood collection tubes require immediate plasma separation to prevent protein contamination from lysed blood cells and activated platelets. This creates logistical barriers for multi-site studies and limits sample collection to locations with centrifugation capabilities. Protein Plus BCT’s room temperature stabilization for up to 5 days eliminates these constraints, enabling flexible sample collection and transport while maintaining the integrity of plasma protein biomarkers for accurate research results.
Blood cells contain high concentrations of intracellular proteins that differ from circulating plasma proteins. When cells lyse or platelets activate, these proteins are released into plasma and can interfere with biomarker measurements through direct competition in immunoassays or increased background signal in mass spectrometry. Protein Plus BCT limits interference of proteins released from blood cells by preventing cell lysis and platelet activation, ensuring that measured protein levels represent true circulating biomarkers rather than artifacts of sample handling.
