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For Research Use Only. Not for use in diagnostic procedures.
Cell-Free DNA BCT RUO maintains cell-free DNA for up to 14 days at 6 °C to 37 °C* and CTCs for up to 7 days at 15 °C to 30 °C*. It contains a preservative reagent that limits the release of genomic DNA, allowing for isolation of high-quality cell-free DNA, and minimizes the degradation of circulating tumor cells (CTCs)*. Cell-Free DNA BCT RUO eliminates the need for immediate plasma isolation and CTC processing, easing concerns about pre-analytical variation that arises during shipping and handling.
The cell-free DNA and CTCs isolated from stored plasma are suitable for many downstream applications used in research studies, drug discovery and assay development.
*These performance characteristics have not been evaluated by the U.S. Food & Drug Administration
14-day cell-free DNA/genomic DNA sample stability at 6 °C to 37 °C*
7-day CTC sample stability at 15 °C to 30 °C*
Available in 10 mL draw for research use
Eliminates the need for immediate plasma preparation and CTC processing
High-quality cell-free DNA can be used for a wide range of downstream research applications
Allows for room temperature storage and shipping of critical samples
| Description | Item Number |
|---|---|
| 6-tube pack (10.0 mL) – 16mm x 100mm, RUO** | 218961** |
| 100-tube box (10.0 mL) – 16mm x 100mm, RUO** | 218962** |
| 1000-tube case (10.0 mL) – 16mm x 100mm, RUO** | 218992** |
**Not for Clinical Use.
Cell-Free DNA BCT RUO is available in three versions depending on region and intended use. The RUO (Research Use Only) version is for Research Use Only. The CE marked version is an in vitro diagnostic device for export markets outside the U.S. The IVD version is FDA cleared for specific NGS assays in the United States. Performance characteristics for the RUO and CE versions have not been evaluated by the U.S. Food & Drug Administration. See the CE page or the IVD page for those versions.
Cell-Free DNA BCT RUO maintains cell-free DNA for up to 14 days at 6 °C to 37 °C and circulating tumor cells (CTCs) for up to 7 days at 15 °C to 30 °C. This extended stability eliminates the need for immediate plasma isolation and CTC processing, easing concerns about pre-analytical variation during shipping and handling.
The cell-free DNA and CTCs isolated from plasma stored in Cell-Free DNA BCT RUO are suitable for many downstream applications used in research studies and assay development, including next-generation sequencing, digital PCR and other molecular analyses.
Yes, Cell-Free DNA BCT RUO allows for room temperature storage and shipping of critical samples. The tubes maintain sample integrity across a wide temperature range (6 °C to 37 °C for cfDNA), eliminating the need for cold chain logistics and reducing costs and complications associated with temperature-controlled transport.
Liquid biopsy research relies on detecting rare circulating biomarkers like cell-free DNA and CTCs in blood samples. Without stabilization, white blood cells can lyse during sample handling and transport, releasing massive amounts of genomic DNA that overwhelms the rare cell-free DNA signal. Cell-Free DNA BCT RUO prevents this contamination through its proprietary stabilization technology, enabling researchers to obtain high-quality samples even when immediate processing is not possible or when samples must be shipped to centralized testing facilities.
Pre-analytical variation is a major source of inconsistency in biomarker research, occurring during sample collection, transport and storage. Cell-Free DNA BCT RUO minimizes this variation by maintaining draw-time concentrations of cell-free DNA and CTCs for extended periods at room temperature. This standardization across samples improves data quality, reduces experimental variability and enables more reliable discovery and validation of biomarkers in research studies.
Streck Cell-Free DNA BCT RUO is designed to be compatible with a wide range of commercially available extraction methods. For cfDNA extraction, Streck has tested the following:
For PBMC isolation, Streck has tested STEMCELL Technologies EasySep™ Direct Human PBMC Isolation Kit
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